Title: Pregnancy outcome in hyper-responders during controlled ovarian hyperstimulation in IVF/ICSI cycles
Abstract: Objective: To evaluate the pregnancy outcome in hyper-responders during controlled ovarian hyperstimulation with GnRH agonist and rFSH in IVF/ICSI cycles.Methods: This retrospective study included 1,058 IVF/ICSI cycles performed from January 2003 to December 2005 in our reproductive center.Ovarian responses were grouped according to the percentile E_2 on the day of hCG administration.Group A consisted of normal responders defined as women with oestradiol concentrations between the 25th and 75th percentiles(4,302-10,791 pmol/L,530 cycles),group B consisted of moderately high responders,defined as women with oestradiol concentrations between the 75th and 90th percentile(10,792-14,669 pmol/L,159 cycles).Group C was set the cut-off concentration for hyper-responders as the 90th percentile and above(≥14,670 pmol/L,105 cycles). The pregnancy outcomes among three groups were analyzed with ANVOA and chi-square test.Results: The numbers of follicles,oocytes and fertilized embryos were significantly different in three groups(P0.05),but there were no differences in oocyte retrieval rate,fertilization rate and high-grade embryo rate.Pregnancy rate was lower but with no significantly difference in hyperresponders' group(P0.05).Implantation rate in group C was lower than that in normal responders(21.38% vs.29.74%,P0.05).There were no difference in miscarriage rate during the first trimester among three groups(P0.05).Women with moderate and severe ovarian hyperstimulation increased with the E_2 levels(P0.05). Conclusions: The results suggest that hyper-response to the controlled ovarian hyperstimulation would not affect the oocyte quality and pregnancy rate,but significantly affect the implantation rate.High oestradiol concentrations during ovarian stimulation might expose the embryos to a sub-optimal endometrial environment.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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