Title: Experimental Study on Non-alcoholic Fatty Liver with Suxiao Xiaozhi Decoction
Abstract: Objective:Experimental study on the anti-rat NASH effect of Suxiao Xiaozhi Decoction(SXD).Methods:Fouty SD rats were randomly divided into 4 groups,normal group(group A),model group(group B),group of SXD(group C) and group of fenofibrate(group D).The rats in normal group were fed with normal diet,and the rats in other groups were fed with fat emulsion.After three weeks,fatty liver model was established.Then,give group C and group D the treatment,and at the same time,continue to feed the three groups with fat emulsion.The treatment will be continued for four weeks.And at the twelve hours after the last administration of the drugs,rats in all groups would be killed.Blood samples for detecting ALT,AST activity and TG,TC contents were collected.Histopathological examination was also performed for liver tissue.Results:The SXD could significantly lower serum ALT,AST activity,and lower serum TG,TC contents.In the liver tissue,SXD could lower the TG,TC contents as well.And it could markedly ameliorate the liver damage(P0.05).Conclusions:SXD can protect liver against NASH which could induced.Maybe,the mechanism is the compound can enhance the elimination of OFR.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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