Title: Observations on the changes of microvascular function in experimental myocardial stunning with intravenous myocardial contrast echocardiography
Abstract:Objective To observe the changes of microvascular function during myocardial stunning and the effect of assessing with myocardial contrast echocardiography(MCE). Methods Twelve dogs underwent 15 or 60...Objective To observe the changes of microvascular function during myocardial stunning and the effect of assessing with myocardial contrast echocardiography(MCE). Methods Twelve dogs underwent 15 or 60 min of left anterior descending coronary artery (LAD)occlusion, followed by 120 min of reperfusion. MCE was performed intravenously using C 3F 8 exposed sonicated dextrose albumin at baseline, during coronary occlusion, and at 5,30,60,90,and 120 min after reperfusion. At baseline, 5,60,and 120 min after reperfusion, acetylcholine(ACH) and nitroglycerin(NG) were given from aortic root injections and MCE was repeated, respectively. End systolic images in short axis were acquired in harmonic mode and digitized on line. Background subtracted peak videointensity(PVI)in stunned myocardium area was measured from MCE and the ratios of PVI post and pre ACH or NG (ACH PVIR, NG PVIR) were calculated. Results A marked increase in PVI occurred in all dogs with stunned myocardium in the early period of reperfusion and the PVI restored to the pre occlusion level after 60 min of reperfusion. NG PVIR were markedly declined in the early period of reperfusion, and restored to their pre occlusion levels at 60 and 120 min of reperfusion both in 15 and 60 min LAD occlusion groups. However, significantly decreased ACH PVIR was only seen in the early period of reperfusion in the 15 min LAD occlusion group and lasted for whole period of reperfusion in the 60 min LAD occlusion group.Conclusions Stunned myocardium is hyperemic in the early period of reperfusion and the blood perfusion restores to normal level in a short time after reperfusion. There are microvascular endothelium damage and endothelium dependent dilatation impairments in stunned myocardium, and their improving speeds might be related to original ischemia duration.Read More
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
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