Title: Comparison of efficacy between Glipizide GITS and Gliclazide in the treatment of Chinese patients with type 2 diabetes mellitus
Abstract: Objective To compare the clinical efficacy of once daily regimen with Glipizide GITS (Glucotrol XL) and multiple dose regimen with Gliclazide (Diamicron) in the treatment of Chinese patients with type 2 diabetes mellitus. Methods One hundred and fifty one Chinese type 2 diabetic patients meeting the 1985 WHO diagnostic criteria were recruited from 4 clinical centers. The patients were assigned to Glipizide GITS (78 cases) or Gliclazide (73 cases) treatment group. Results The trial consisted of 1 week washout period followed by 6 week dosage regulation period and 6 week dosage maintenance period. Comparing to the baseline, HbA 1c , fasting plasma glucose (FPG) and 24 hour glucose profile levels in two groups were significantly reduced after 3 month treatment. In Glipizide GITS group, the mean reductions of blood HbA 1c and FPG level were 0.55% and 2.05 mmol/L respectively (P0.001); in Gliclazide group, the mean reductions of blood HbA 1c and FPG level were 0.47% and 2.13 mmol/L respectively (P0.01). The differences in reductions of HbA 1c and FPG level between the two groups were not statistically significant. The incidence of adverse events in two groups was similar, nolaboratoryprovedhypoglycemia(plasmaglucose≤2.78 mmol/L) was observed. Hepatic function, renal function and lipid profile did not significantly change after treatment. Conclusion Once daily regimen with Glipizide GITS provides an effective 24 hour control of plasma glucose levels for Chinese patients with type 2 diabetes. Compared to multiple dosage regimen of Gliclazide, Glipizide GITS is equally well safe and effective.
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
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