Title: Effects of Porphyromonas gingivalis vesicles on MMPs gene expression of gingival epithelial cells.
Abstract: Objective:To study the effects of Porphyromonas gingivalis vesicles on matrix metalloproteinases(MMPs) gene expression of gingival epithelial cells and the pathogenesis of Porphyromonas gingivalis in periodontitis. Method:The effects of Porphyromonas gingivalis vesicles on MMP-1 and MMP-3 mRNA expression of gingival epithelial cells were determined by Real-time RT-PCR. Resulut:Porphyromonas gingivalis vesicles significantly up-regulated MMP-1 and MMP-3 mRNA expression of gingival epithelial cells. Conclusion:Cellular inflammatory responses of gingival epithelial cells induced by Porphyromonas gingivalis may contribute to the initiation and progression of periodontitis.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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