Title: Tongluo Yizhi Powder's Effect on Expression of P53 Protein of Hippocampus CA1 Area of Rats with Vascular Dementia
Abstract:Objective: To explore the effect of Tongluo Yizhi power (TLYZP)on expression of P53 protein in hippocampus CA1 area of rat with vascular dementia. Methods: The rat model of vascular dementia was build...Objective: To explore the effect of Tongluo Yizhi power (TLYZP)on expression of P53 protein in hippocampus CA1 area of rat with vascular dementia. Methods: The rat model of vascular dementia was build by repeated legation of bilateral common carotid arteries (CCA)together. The rats were randomly divided into sham operation group, model group, TLYZP high and low dose group, Nimodipine group with 10 rats in each group. After 3 weeks,the expression of P53 in hippocampus CA1 were detected. Results: The sham-operated group of hippocampus CA1 area has no P53-positive cells. The average gray value of P53 positive cells of hippocampus CA1 area in TLYZP and nimodipine group were significantly higher than the model group (P0.05). Conclusion: TLYZP could prominently decrease the expression of P53 and inhibit apoptosis of vascular dementia that caused by brain injury in rats. It has a protective effect on brain tissue, which could be one of mechanism for treatment vascular dementia.Read More
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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