Title: Experimental Research on Tiaozhi Hugan Decoction Treatment on Rat Fatty Livers Induced by High Fatty Diet
Abstract: Objective:Observe theraputic effect of Tiaozhi Hugan decoction and investigate its pharmcodynamics.Methods:64 SD male rats were fed a normal diet for one week then they were randomly divided into two groups,one was normal group which were 12 rats fed normal diet,the other,which were 52 rats fed high fatty diet for 12 weeks.At the end of 13th weed,8 rats,2 rats were fed normal,6 rats were fed high fat diet,were scarified to test fatty liver model.Then 44 rats,which were fed high fatty diet,were randomly divided into 4 groups of eleven each:model control group,DongBao GanTai group,seaweed decoction group and Tiaozhi Hugan decoction group.They were fed high fatty diet continuously for 8 weeks.At the same time model control group rats were given distilled water 10mL/(kg·d)by gastrolavage,seaweed decoction group rats were fed seaweed decoction 20g/(kg·d).Dongbao Gantai group rats were fed Dong Bao Gantai,0.5g/(kg·d),Tiaozhi Hugan decoction group were fed Tiaozhi Hugan decoction 10mL/(kg·d)(contained seaweed 20g/kg).At the end of 21th week,all rats were scarified,body weight,liver index(liver/body weight ratio)serum ALT,AST,TG,TC,MDA,SOD,fasting blood glucose,fasting insulin and liver TG were assayed,the liver histology changes of all rats were observed also.Results:(1)Compared with model control group and DongBao Gantai group,the level of body weight,liver index in seaweed group and Tiaozhi Hugan decoction group were lower significantly(P0.01).(2)The level of TC in Tiaozhi Hugan decoction group was lower than that in model control group,Dongbao Gantai group,seaweed decoction group(P0.01) and higher than that in normal GrouP(P0.05).(3)Compaired with model control and Dongbao Gantai group,the level of TG in serum and liver in seaweed group and Tiaozhi Hugan group was lower(P0.01).(4)The level of HLD-C in Tiaozhi Hugan group was high than that in normal group,model control group,Dongbao Gantai group,seaweed decoction group(P0.01).(5)The level of ALT、AST in model control group,Dongbao Gantai group and seaweed decoction group was higher than that in normal group and Tiaozhi Hugan decoction group.(6)Compared wth model Control Group,Dongbao Gantai group,seaweed decoction group,the level of MDA in Tiaozhi Hugan decoction was lower significantly(P0.01),the level of SOD was higher significantly(P0.01).(7) The level of HOMA-IR in Tiaozi Hugan group was lower than that in model control,Dongbao Gantai group(P0.01).(8) The pathologic change of livers showed that Tiaozhi Hugan decoction has better effect on anti-fatty liver and improving lipid hepatitis than DongBao GanTai decoction.Concluson:It was suggestion that the pharmacodynamics and therapeutic function of Tiaozhi Hugan Decoction to fatty liver induced by high fatty diet were:(1) Lowering body weight and liver index.(2) Adjusting lipometabolism:reducing TC(in serum)TG(in serum and liver).(3) Improving liver function:lowering ALT and AST.(4) Anti-lipid Peroxide: increasing SOD and Lowing MDA in serum.(5) Anti-insulin resistance.(6) Improving lipidic aggradation and inflammation in liver.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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