Title: Renoprotective effects of losartan combined with captopril in spontaneo usly hypertensive rats
Abstract: OBJECTIVE To observe the effects of losartan and c aptopril on renal structure and function in spontaneously hypertensive rats(SHR) .METHODS Thirty SHRs were gorged with losartan (30 mg·kg -1 ·d -1 ), captopril (100 mg·kg -1 ·d -1 ),losartan (15 mg·k g -1 ·d -1 ) + captopril (50 mg·kg -1 ·d -1 ) or water respec tively for 15 weeks in the treating and control groups.The blood pressure and pr oteinuria were assessed, the levels of angiotensin Ⅱ(AngⅡ) and transforming gr owth factor(TGF)β 1 were detected, and renal tissues were examined routinely b y optical and electron microscopy respectively.RESULTS The e xcretion of proteinuria was significantly decreased in the treating groups compa red with the control group.There was a decrease TGFβ 1 and collagen Ⅳ deposit ion in the treatment group, and further lower in losartan + captopril group.Losa rtan and captopril attenuated the injuries of small arteries.CONCLUSI ON The combination of losartan with captopril may attenuate renal damag e,they had synergistic action when used together.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot