Title: Expression of podoplanin in non-small cell lung carcinoma and its relationship with tumor lymphatic metastasis
Abstract: Objective To detect the expression of podoplanin in non-small cell lung carcinomas and to analyze its relationship with lymph node metastasis.Methods Immunohistochemistry(SP) was used to detect the expression of VEGFR-3,CD31 and lymphatic marker podoplanin in 46 archival surgical specimens of human NSCLC and 8 pulmonary poroma.Assessments of microvessel density were performed and then its relationship with lymph node metastasis was analyzed.Results No substantial association was found between the number of podoplanin+ vessels and the number of CD31~+ or VEGFR-3~+ vessel(the spearman rank correlation coefficient 0.23,P=0.61;0.09,P=0.84),high counts of VEGFR-3~+ vessels were associated with high CD31~+ vessel counts(coefficient 0.80,P=0.031,P0.05).LVD in pulmonary poroma were distinctly lower than LVD in NSCLC(P0.05).Compared with that of NSCLC with negative lymph node metastasis,LVD in NSCLC with positive lymph node metastasis increased significantly(P0.05).Conclusion Podoplanin is a more specific lymphatic vessel marker in NSCLC tissues and most of the VEGFR-3 positive vessels are blood vessels and not lymph vessels.Our results suggested that podoplanin could be used as a marker for the detection of lymphatic metastasis and as a one of the factors for prognosis.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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