Title: Protective Effect of Ulinastatin on Ischemia-reperfusion Injury in Patients Undergoing Liver Transplantation
Abstract: Objective To investigate the protective effects of ulinastatin on ischemia-reperfusion injury in the patients undergoing liver transplantation.MethodsTwenty-six patients with hepatic carcinoma were divided into two groups at random (Group C as control and Group W, n=13). All the patients’ liver function was normal before operation. In Group W, the patients received ulinastatin (10 KU/kg). The plasma levels of ALT, AST, and TBIL were measured before operation C (T1), 20min after recovering hepatic circulation (T2),1 h after recovering hepatic inflow (T3), 1, 3 and 5 days after operation (T4-T6).ResultsAt all the time point after operation, the plasma levels of ALT, AST, TBIL were lower in Group W than in Group C. ALT and AST at T2-5 in Group W were remarkably lower than that in Group C (P0.05), and the plasma level of TBIL in Group W was remarkably lower than that of Group C only in the first day.ConclusionIt is suggested that ulinastatin can relieve the ischemia-reperfusion injury in the patients undergoing liver transplantation, and promote the recovery of liver function after liver transplantation.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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