Title: Experimental study of neurotropism following end-to-side neurorrhaphy of sensory nerve
Abstract: Objective: To detect whether there is neurotropism following end-to-side neurorrhaphy of sensory nerve. Methods: Twenty female Sprague-Dawley rats were divided into 2 groups: end-to-side neurorrhaphy group and normal control group. In the end-to-side group,the cutaneous antebrachii medialis nerve(CAM) was transected,then an 1 mm epineural window was created on the ulnar nerve. Distal end of CAM nerve was sutured to the windowed ulnar nerve by means of end-to-side neurorrhaphy. In the normal control group,CAM and ulnar nerves were exposed. One year post-operatively,evaluations including acetylcholinesterase(AchE)stain and retrograde Fluoro-Gold neuron tracing were conducted. Results: AchE staining showed that in the end-to-side group myelinated nerve fiber count was 23.0% as compared to normal control group (P0.01),and the percentage of motor fibers in the end-to-side group was 0.34±0.16 (P 0.01). Retrograde neuron tracing demonstrated that the motor neuron counts in CAM end-to-side group were 150.9±104.8 (P 0.01),and the percentage of motor neuron in the end-to-side group was 0.27±0.11 (P 0.01). Conclusion: Neurotropism in collateral spouting after end-to-side neurorrhaphy of sensory nerve is not significant.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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