Title: The changes and clinical significance on the expressions of Th17,Th1 and cytokines in patients with systemic lupus erythematosus
Abstract: Objective To investigate the expressions of T helper cell 17(Th17),T helper cell 1(Th1) and cytokines such as interleukin 17(IL-17),interleukin 23(IL-23) and interferon-gamma(IFN-γ) in peripheral blood from patients with systemic lupus erythematosus(SLE),and their clinical significance.Methods According to SLE disease activity index(SLEDAI),38 patients with SLE were classified into active group(SLEDAI≥10,20 patients) and inactive group(SLEDAI10,18 patients).Flow cytometry was used to analyze the percentages of Th17 and Th1 in 38 patients with SLE and 20 healthy controls.The expressions of IL-17,IL-23 and IFN-γ were determined by enzyme-linked immunosorbent assay(ELISA),and the results were analyzed statistically.Results The percentage of Th17 in patients with SLE was significantly higher than that in healthy controls(P0.05),and the percentage of Th17 in active group was higher than that in inactive group(P0.05),but the expression of Th1 had no statistical significance with that of healthy controls(P0.05).The expressions of IL-17,IL-23 and IFN-γ in patients with SLE were higher than those in healthy controls(P0.05).The expression of Th17 and the levels of IL-17 and IL-23 were positively correlated with SLEDAI(r=0.537,0.428 and 0.525,P0.05).Conclusions The expression of Th17 and the levels of IL-17,IL-23 and IFN-γ increase in patients with SLE,and Th17 and Th1 may play important roles in the pathogenesis of SLE.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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