Title: Clinical research on esophageal transection portal- azygos disconnection combined with liver and spleen resection in the treatment of patients with primary hepatocellular carcinoma associated with Hypersplenism
Abstract: Objective To investigate the impact of surgical method on judging the operative safety and the impact of patient selection on the effect of surgery in patients with primary hepatocellular carcinoma associaled with portal hypertension and hypersplenism.Methods Clinical data of 60 patients with primary hepatocellular carcinoma associated with portal hypertension and hypersplenism treated in our hospital from May 2005 to Novenber 2011 were retrospectively analyzed,including 30 patients treated by the esophagus transection portal- azygos disconnection combined with liver and spleen resection,30 patients treated by simple liver resection.Between two groups the liver function, the degree of cirrhosis,preoperative and postoperative changes in blood and liver function,postoperative complications, and other indicators were compared,for determining the safety of surgery and the impact of patient selection on surgical effect.Results Sixty patients were followed up for 5 months to 5 years,with the average of(12.3±2)months,In the treatment group 20 cases were cured,total effective rate was 96.7%,recurrence rate was 16.7%; in control group were 15 cases,total effective rate was 80.0%,the recurrence rate was 30.0%(P0.05),in control group,there was no significant difference in preoperative and postoperative platelet and WBC;in treatment group,platelets and WBC after treatment was significandy higher than that before treatment.5-year disease-free survival after the treatment in the treatment group and control groups were 10 cases(33.3%) and 5 casese(16.7%) respatively,the difference was significant(P0.05).Conclusion For patients with primary hepatocellular carcinoma associaled with portal hypertension and hypersplenism,concomitant esophageal transection patal- azygos disconnection combined with resection of the liver and spleen is feasible.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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