Publication Information

{'id': 'https://openalex.org/W2364944693', 'doi': None, 'title': 'The effect of 5-Aza-CdR on TIMP-3 gene in hepatocellular carcinoma cells', 'display_name': 'The effect of 5-Aza-CdR on TIMP-3 gene in hepatocellular carcinoma cells', 'publication_year': 2013, 'publication_date': '2013-01-01', 'ids': {'openalex': 'https://openalex.org/W2364944693', 'mag': '2364944693'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://en.cnki.com.cn/Article_en/CJFDTOTAL-XDXH201306004.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764380129', 'display_name': 'Modern Digestion & Intervention', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5049056511', 'display_name': 'Zeng We', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210116575', 'display_name': "Guangzhou First People's Hospital", 'ror': 'https://ror.org/02bwytq13', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116575']}, {'id': 'https://openalex.org/I92039509', 'display_name': 'Guangzhou Medical University', 'ror': 'https://ror.org/00zat6v61', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I92039509']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Zeng We', 'raw_affiliation_strings': ['Guangzhou Key Laboratory of Digestive Disease, Department of Gastroenterology, First Municipal People′ s Hospital of Guangzhou, Guangzhou Medical University'], 'affiliations': [{'raw_affiliation_string': 'Guangzhou Key Laboratory of Digestive Disease, Department of Gastroenterology, First Municipal People′ s Hospital of Guangzhou, Guangzhou Medical University', 'institution_ids': ['https://openalex.org/I4210116575', 'https://openalex.org/I92039509']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5049056511'], 'corresponding_institution_ids': ['https://openalex.org/I4210116575', 'https://openalex.org/I92039509'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 65}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13157', 'display_name': 'Cancer-related gene regulation', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9794, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cpg-site', 'display_name': 'CpG site', 'score': 0.85688883}, {'id': 'https://openalex.org/keywords/dnmt1', 'display_name': 'DNMT1', 'score': 0.52965444}, {'id': 'https://openalex.org/keywords/dna-methyltransferase', 'display_name': 'DNA methyltransferase', 'score': 0.4943874}, {'id': 'https://openalex.org/keywords/pyrosequencing', 'display_name': 'Pyrosequencing', 'score': 0.4624977}, {'id': 'https://openalex.org/keywords/bisulfite-sequencing', 'display_name': 'Bisulfite sequencing', 'score': 0.42922586}], 'concepts': [{'id': 'https://openalex.org/C33288867', 'wikidata': 'https://www.wikidata.org/wiki/Q518328', 'display_name': 'Methylation', 'level': 3, 'score': 0.90755486}, {'id': 'https://openalex.org/C140173407', 'wikidata': 'https://www.wikidata.org/wiki/Q1138358', 'display_name': 'CpG site', 'level': 5, 'score': 0.85688883}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.7087432}, {'id': 'https://openalex.org/C91965660', 'wikidata': 'https://www.wikidata.org/wiki/Q415875', 'display_name': 'Methyltransferase', 'level': 4, 'score': 0.6469834}, {'id': 'https://openalex.org/C2778019345', 'wikidata': 'https://www.wikidata.org/wiki/Q1148337', 'display_name': 'Hepatocellular carcinoma', 'level': 2, 'score': 0.5765771}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.55733126}, {'id': 'https://openalex.org/C175211621', 'wikidata': 'https://www.wikidata.org/wiki/Q14907998', 'display_name': 'DNMT1', 'level': 5, 'score': 0.52965444}, {'id': 'https://openalex.org/C2779979206', 'wikidata': 'https://www.wikidata.org/wiki/Q1154602', 'display_name': 'DNA methyltransferase', 'level': 5, 'score': 0.4943874}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4898052}, {'id': 'https://openalex.org/C125009961', 'wikidata': 'https://www.wikidata.org/wiki/Q2342248', 'display_name': 'Pyrosequencing', 'level': 3, 'score': 0.4624977}, {'id': 'https://openalex.org/C189235521', 'wikidata': 'https://www.wikidata.org/wiki/Q4087270', 'display_name': 'Bisulfite sequencing', 'level': 5, 'score': 0.42922586}, {'id': 'https://openalex.org/C105580179', 'wikidata': 'https://www.wikidata.org/wiki/Q188928', 'display_name': 'Messenger RNA', 'level': 3, 'score': 0.42480224}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4219342}, {'id': 'https://openalex.org/C16685009', 'wikidata': 'https://www.wikidata.org/wiki/Q335057', 'display_name': 'Andrology', 'level': 1, 'score': 0.3831478}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.34757584}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.3249998}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.26761895}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.19635218}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://en.cnki.com.cn/Article_en/CJFDTOTAL-XDXH201306004.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764380129', 'display_name': 'Modern Digestion & Intervention', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Life below water', 'score': 0.87, 'id': 'https://metadata.un.org/sdg/14'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3031919814', 'https://openalex.org/W2910111835', 'https://openalex.org/W2386456186', 'https://openalex.org/W2385052755', 'https://openalex.org/W2383753221', 'https://openalex.org/W2381482069', 'https://openalex.org/W2378413371', 'https://openalex.org/W2376225896', 'https://openalex.org/W2368252264', 'https://openalex.org/W2363799924', 'https://openalex.org/W2359910668', 'https://openalex.org/W2358528191', 'https://openalex.org/W2316685535', 'https://openalex.org/W2122629082', 'https://openalex.org/W2084524058', 'https://openalex.org/W2071064469', 'https://openalex.org/W2044366730', 'https://openalex.org/W2000940387', 'https://openalex.org/W1974435624', 'https://openalex.org/W1960096185'], 'abstract_inverted_index': {'Objective': [0], 'The': [1, 107, 120], 'aim': [2], 'of': [3, 14, 40, 45, 59, 81, 109, 152, 161], 'this': [4], 'study': [5], 'is': [6], 'to': [7, 21, 36, 98, 142], 'investigate': [8], 'the': [9, 23, 38, 43, 79, 101, 131, 138, 150, 153, 159], 'CpG': [10, 50, 56, 102, 111, 154], 'island': [11, 51, 103, 155], 'methylation': [12, 29, 52, 57, 104, 108, 132, 156], 'status': [13, 58], 'TIMP-': [15], '3': [16], 'in': [17, 113, 137, 165], 'HCC': [18, 24, 60, 68, 166], 'cell': [19], 'lines,': [20], 'treate': [22], 'cells': [25, 61, 69], 'that': [26, 123], 'exhibit': [27], 'positive': [28], 'with': [30, 72], 'DNA': [31, 73], 'methyltransferase': [32, 74], 'in-': [33], 'hibitor(5-Aza-CdR),': [34], 'and': [35, 48, 78, 91, 116, 130, 157], 'observe': [37], 'influence': [39], '5-Aza-CdR': [41, 146], 'on': [42], 'expression': [44, 84, 126, 160], 'TIMP-3': [46, 55, 82, 110, 124, 162], 'mRNA': [47, 83, 125], 'its': [49], 'degree.': [53], 'Methods': [54], 'were': [62, 70], 'examined': [63], 'using': [64], 'MSP': [65], 'assay.': [66], 'Methylation-positive': [67], 'treated': [71], 'inhibitor(5-Aza-': [75], 'CdR)(intervention': [76], 'group),': [77], 'difference': [80], 'was': [85, 96, 118, 127, 134], 'observed': [86], 'between': [87], 'interven-': [88], 'tion': [89], 'group': [90, 140], 'control': [92, 143], 'group.': [93, 144], 'Pyrosequencing': [94], 'method': [95], 'applied': [97], 'quantitatively': [99], 'examine': [100], 'percentage.': [105], 'Results': [106], 'islands': [112], 'C3A,': [114], 'HepG-2,': [115], 'Hep-3B': [117], 'positive.': [119], 'results': [121], 'showed': [122], 'increased(P': [128], '0.05)': [129, 136], 'level': [133, 151], 'decreased(P': [135], 'intervention': [139], 'compared': [141], 'Conclusion': [145], 'could': [147], 'remarkably': [148], 'reduce': [149], 'increase': [158], 'mR-': [163], 'NA': [164], 'cells.': [167]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2364944693', 'counts_by_year': [], 'updated_date': '2024-12-15T14:47:53.644221', 'created_date': '2016-06-24'}