Title: Preliminary study of podophyllotoxin and its derivatives on angiogenesis of chick chorioallantoic membrane
Abstract: Objective: To develop a chick chorioallantoic membrane(CAM) model in vivo for observing the effects of podophyllotoxin and its derivatives on the angiogenesis of CAM.Methods: Ethanol solution of podophyllotoxin and its derivatives loaded with gelatin sponge carrier were implanted on chick CAM surface of 7-day-old fertilized eggs and incubated for 72 hours.Cut down the CAM,took photos with a stereomicroscope,counted the number of CAM blood vessel,and analyzed the effects of the angiogenesis of CAM.Results: Deoxypodophyllotoxin,ketopicropodophyllotoxin,picropodophyllotoxin and podophyllotoxin had an obvious effect on antiangiogenisis of CAM;podophyllotoxone and isopicropodophyllotoxin did not have obvious effect.Conclusion: The anti-tumor activity of podophyllotoxin and its derivatives is concerning with its function of antiangiogenisis.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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