Title: The protective effect of high density lipoprotein on endothelium dependent vasodilatation
Abstract: Objective The aim of this study was to evaluate the correlation between serum high density lipoprotein cholesterol (HDL C) levels and endothelium dependent dilatation of brachial arteries. Methods Serum lipids and the dilatation changes of brachial arteries during reactive hyperemia and after sublingual glyceryl trinitrate (GTN) were measured in 105 subjects in whom the total cholesteol levels were relatively normal. There were 71 patients with established coronary heart disease and 34 controls. Results Both flow mediated dilatation (FMD) and GTN induced dilatation of brachial arteries in patients with coronary heart disease were much reduced compared with control group (2 61%±2 91% vs 8 01%±4 72% and 17 22%±6 76% vs 23 13%±8 61%, respectively, P 0 001 for all). Multiple linear stepwise regression analysis showed that FMD of brachial arteries was positively related to HDL C ( r= 0 324, P =0 002). No significant correlation was observed, however, between FMD of brachial arteries and total cholesterol, low density lipoprotein cholesterol or triglycerides and between GTN induced dilatation of brachial arteries and above serum lipids. All subjects were divided into two groups (group A and Group B) acccording to the degree of FMD of brachial arteries. The FMD of brachial arteries was ≤4% in group A and 4% in group B. The serum HDL C level in group A was significantly lower than that in group B (1 15±0 26 mmol/L vs 1 38±0 50 mmol/L, P 0 01). Conclusion Both endothelium dependent and endothelium independent vasodilatation is impaired in patients with coronary heart disease. HDL C exerts a protective effect on endothelium dependent vasodilatation. The protective effect might contribute to the beneficial effects of HDL C against atherosclerosis.
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
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