Title: Advance in the secretory expression of recombinant protein in escherichia coli
Abstract: Escherichia coli is one of the most widely used hosts for the production of recombinant proteins.Production of secretory proteins in escherichia coli provides several advantages over expression in the cytoplasm.Periplasm provides the oxidative environment to facilitate correct disulfide bonding and protein folding.It also allows correct processing of N-terminal amino acid during secretion.This review discusses recent advances in secretory and extracellular production of recombinant proteins so as to improve the biological activity of the heterologous proteins.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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