Title: Influence of combined immunosuppressants on CD62L, CD11a expression of lymphocytes from peripheral blood in renal allograft recipients and Implication
Abstract: Objective To investigate the influence of combined immunosuppressants on CD62L and CD11a expression of lymphocytes from peripheral blood in renal allograft recipients and implication. Methods The dynamic changes in CD62L and CD11a levels in lymphocytes in different time points were examined by using mAb FACS immunofluorescence technique in 10 renal allograft recipients in stable course (stable group) and 10 with acute rejection (rejection group) after operation. The recipients were subjected to triple drug therapy and methylprednisolone (MP) was used for anti rejection treatment and in acute stage and antithymocyte lymphocyte globulin (ATG) was introduced simultaneously in the early stage (within 10 days). Results The expression of CD11a in lymphocytes was increased after administration of immunosuppressants in stable group, reaching the peak at 9th day [(22.9±8.9), P 0.01], and returned after stopping ATG, but significantly lower than in the preoperative group. No significant difference in CD62L between the suppressants treated group and preoperative groups was found. In rejection group, both CD62L and CD11a expression was obviously increased at the 5th to 7th day of rejection, and CD11a was rapidly decreased, but CD62L showed no change.Conclusion The immunosuppressants (especially MP) can suppress the expression of CD11a in lymphocytes evidently. ATG may play an important role in maintaining lower level of CD11a and inducing the immunologic tolerance.
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
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