Title: The value of C-reactive protein in the differential diagnosis of infectious diseases
Abstract: Objective To explore the change of serum concentration of C-reactive protein(CRP) in bacterial infectious diseases.Methods Immunoturbidimetric assay was performed to detect the serum concentration of CRP in 428 patients with bacterial infection and 55 patients with viral infection.Erythrocyte sedimentation rate(ESR),white blood cell count(WBC) and neutrophil percentage were also carried out at the same time.Results Serum levels of CRP in patients with bacterial infections were significantly higher than in the controls(P0.01),and serum levels of CRP in patients with acute bacterial infections were also significantly higher than in patients with chronic bacterial infections(P0.01).There was certain correlation of ESR,WBC count and neutrophil cell percentage with the concentration of CRP during the acute stage of bacterial infection.But the sensitivity of the three detections was lower than CRP.The increase of serum concentration of CRP in patients with viral infection was not obvious,and was with no statistical difference,compared with healthy controls(P0.05).Conclusion The determination of CRP contributes to the differential diagnosis of bacterial infectious diseases,and the sensitivity and specificity of it are better than traditional detections.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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