Title: Effect of salvianolic acid B on endothelin release and TXA2/PGI_2 system in myocardial ischemia reperfusion injury in rats
Abstract: Objective To investigate the effect of salvianolic acid B (Sal B) on the release of endothelin (ET) and TXA 2/PGI 2 system in myocardial ischemia reperfusion injury ( MIRI ) of rat.Methods MIRI model of rat was made by reperfusion injury about 120 minutes after myocardial ischemia about 30 minutes. The contents of ET, TXB 2 and 6-Keto-PGF 1α were detected by the method of radioimmunity.Results The Sal B could reduce the release of ET and TXB 2 and increase the content of PGI 2.Conclusions Sal B could relieve MIRI of rat probably by reducing ET of plasma, ameliorating the balance of TXA 2/PGI 2 system and protecting the injured myocardial cell.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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Cited By Count: 1
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