Title: EFFECT OF DIFFERENT MANAGEMENTS ON THE GUT MICROBIOTA IN PERIOPERATIVE PATIENTS WITH RECTAL CANCER
Abstract: Objective To investigate the effect of antibiotics,bowel preparation,and postoperative drink and food on gut microbiota in perioperative patients with rectal cancer.Methods Forty patients with rectal cancer were divided into four groups in random: group 1(control group),group 2(bowel preparation),group 3(non-bowel preparation+non-postoperative fasting),and group 4(non-bowel preparation+non-postoperative fgasting+postoperative antibiotics-restricted).Corresponding measures were adopted in perioperation,preoperative stool was collected and inoculated to E.coli,Bacteroides,Bifidobacterium,Lactobacillus,Enterococcus,and peptostreptococcus on selective culture plate and cultured.Changes of gut flora among the four groups were compared.Results Postoperatively,the microbial population in each group changed significanly as compared with before surgery,general bacterial population obviously decreased(t=14.784,P0.05),E.coli counts increased(t=21.727,P0.05),while bifidobacteria,Peptostreptococcus,Lactobacillus,Bacteroides and Enterococcus reduced(t=13.894-95.802,P0.05),and bacillus/coccus ratio disordered(t=20.963,P0.05).Compared with group 3,the count of various kinds of bacteria was fewer than that in group 4(F=9.487-483.350,P0.05),and the bacillus/coccus ratio was higher(F=483.350,P0.05).Compared with group 2,Bacteroides and peptostreptococcus level in group 1(F=42.307-483.350,P0.05),and bacillus/coccus ratio declined(F=483.350,P0.05).Compared with group 3,postoperative Bacteroides,enterococcus,bifidobacteria level and bacillus/coccus ratio in group 2 dropped markedly(F=9.487-483.350,P0.05).Conclusion Application of antibiotics,bowel preparation and postoperative fasting may influence perioperative microbial population of intestinal tract to some extent,it is easy to cause disbalance of intestinal microecology,early postoperative feeding may improve this disbalance.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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