Title: Effect of total glucosides of paeony on Th1 cytokine and Th2 cytokine in IBS rats
Abstract: [Objective]To study the effect of total glucosides of paeony(TGP) on Th1 and Th2 cytokine in IBS rats.[Methods]The IBS rat model was made by the combination of stress and basic ovalbumin-sensitized.The rats were randomly divided into five groups: the normal control group,the model control group,the positive control group,the high-dosage TGP group and the low-dosage TGP group.The Th1 and Th2 cytokine in serum and intestinal mucosa of IBS rats were assessed.The regulation of TGP was observed.[Results]Compared with the normal control group,the IL-2 in serum and intestinal mucosa of IBS rats was increased(P0.01),the IL-5 in serum and intestinal mucosa of IBS rats was decreased(P0.05).TGP down-regulated the IL-2 level and up-regulate the IL-5 level in serum and intestinal mucosa of IBS rats(P0.05,0.01).[Conclusion]The Th1/Th2 balance in serum and intestinal mucosa of IBS rats was disorder.TGP could regulate the Th1/Th2 imbalance of IBS rats.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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