Title: Real-time contrast-enhanced ultrasound in differential diagnosis of benign and malignant breast tumors with the length-diameter no more than 2.0cm
Abstract: Objective To investigate the perfusion characteristics and quantitative parameters of time-intensity curve(TIC)in diagnosis of benign and malignant breast tumors(length-diameter≤2.0cm)using real-time contrast-enhanced ultrasound(RT-CEUS).Methods Color doppler flow imaging(CDFI)and CEUS data of patients with breast masses,including 33 cases of malignant tumors and 30 cases of benign tumors were retrospectively studied.Difference of TIC quantitative parameters between benign and malignant breast tumors were compared.And the diagnostic efficiency was evaluated.Results Characteristics of concentric,inhomogeneous,high perfusion and radiate boundary were found in majority of malignant tumors.The boundary of 87.88%(29/33)malignant tumors was fuzzy.While centrifugal,homogeneous and low perfusion were found in benign tumors.The boundary of 83.33%(25/30)benign tumors was clear.Perfusion defect was found in 78.79%(26/33)malignant tumors.Quantitative analysis:Compared with benign tumors,peak intensity(PI)and the slope of TIC ascending branch(k)were higher in malignant tumors(both P0.05).No statistical difference was found of time of peak(TP)between benign and malignant tumors(P0.05).The sensitivity,specificity and accuracy of CDFI in diagnosing malignant breast tumors with length-diameter≤2.0cm was 72.73%(24/33),73.33%(22/30)and73.02%(46/63),respectively.And the sensitivity,specificity and accuracy of CDFI combined CEUS was separately81.82%(27/33),83.33%(25/30)and 82.54%(52/63).Conclusion RT-CEUS perfusion characteristics and TIC quantitative parameters are helpful to increase diagnostic accuracy of breast tumors with length-diameter≤2.0cm.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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