Title: EARLY EFFECT OF ANISODAMINE ON SERUM INFLAMMATORY CYTOKINES IN PATIENTS WITH ACUTE PULMONARY CONTUSION
Abstract: [Objective]To testify the effect of anisodamine on serum inflammatory cytokines in patients with acute pulmonary contusion(APC)at the early period.[Methods]All 60 patients with APC confirmed were randomly divided into the anisodamine therapy group(anisodamine group)and the routine therapy group(control group),each with 30 cases.Routine treatment was given to the control group.In the anisodamine group,patients were given anisodamine injection 1.0 mg·kg-1 by 3 times daily for 2 days plus the routine treatment.At the 24th and 48th hour after treatment,venous blood was sampled to detect serum TNF-α,IL-6,IL-10 concentrations.[Results]No difference of the serum TNF-α,IL-6,IL-10 concentrations was found between the two groups at the 24th hour(P﹥0.05).At the 48th hour after treatment,levels of TNF-α,IL-6 were obviously higher in the control group,while level of IL-10 was obviously highly in the anisodamine group(P﹤0.05).[Conclusion]Anisodamine could reduce the serum level of TNF-α,IL-6,but elevate IL-10 in patients with APC.Anisodamine may play a protective role in APC by regulating TNF-α,IL-6,IL-10.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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