Title: Clinical observation of Wenjing sanhan huayu decoction for treating primary dysmenorrheal(Blood Stasis Syndrome)
Abstract: Objective To observe the efficacy of Wenjing sanhan huayu decoction for primary dysmenorrheal(Blood Stasis Syndrome).Methods 105 patients with blood stasis syndrome of primary dysmenorrheal were divided into two groups:53 cases for the observation group and 52 cases for the control group.The patients of the observation group were treated by Wenjing sanhan huayu decoction.These patients took 100ml of Wenjing sanhan huayu decoction for every time and for three times a day when they suffered dysmenorrheal.The control group took 5g of Shaofu Zhuyu Granule for one time and for three times a day.The effect in relieving menalgia of both groups was evaluated by numerical rating scale(NRS) before and on the third menstrual cycle after treatment.The degree of pain and the TCM symptoms of both groups were evaluated quantitatively.The ratio at uterus artery blood(A/B),resistance index(RI),pulse Index(PI) and PGE2 content in menstrual fluidof these two groups were tested and compared as well.Results ①After treatment,for the observation group,25 patients(47.17%) were clinically cured,16 were treated markedly effectively(30.19%),11 were treated effectively(20.75%) and 1 ineffective(1.89%).The total effective rate was 98.11%.For the control group these treatment effective rates were 16(30.77%),18(34.62%),8(15.38%),and 10(19.23%) respectively,The total effective rate twas 80.77%.The clinical effect of the observation group was significantly higher than that of the control group(P0.05).②For the degree of pain and TCM symptoms of the two groups:on the third menstrual cycles,the NRS scores and symptoms of TCM scores in both group decreased in comparison with those before treatment(P0.01).The decreasing of the observation group was more obvious than that of the control group.③After the treatment of the third menstrual cycles,A/B,RI,PI of both the groups significantly decreased(P0.01).Those of the observation group decreased more significantly.④On the third menstrual cycles,compared with those of those of the control group,the PGF2α,PGE2 levels of the observation group was significantly lower(P0.01).Conclusion Wenjing sanhan huayu decoction helps improve blood circulation and microcirculation of the pelvic cavity.It can dissipate blood stasis and curb the activity of PGF2.Wenjing sanhan huayu decoction also helps regulate the algogenic substances to the normal physiologic balance as to relieve the pain.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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