Title: Histopathologic changes of achondroplasia: a report of 7 autopsied cases
Abstract: Purpose To investigate the pathologic characteristics of achondroplasia.Methods Systemic autopsy was performed in 7 dead foetus of achondroplasia, the length of upper limb and lower limb measured, and the morphology of femur, tibia, fibula, vertebrae, costal bone and ilium observed under microscope.Results The average length of upper limb was 40.6% shorter than that of control group, and the average length of lower limb was 24.4% shorter than that of control group. Microscopically, the junction line between bone and cartilage was uneven and tangled, and hyperplasia of cells in the growth zone of epiphyseal cartilage was not as good as normal. The arrangement of chondrocytes was not in palisade form and linear, endochondral ossification was later than normal fetus of same embryonic age, and capillary was hyperplasia and extended into cartilage irregularly.Conclusions Achondroplasia impacts mainly on endochondral ossification of long bone. There are no malformations in any other organs.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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