Title: Expressing of PTEN Gene and PTEN Gene Mutation in Human Glioma
Abstract: Objective To investigate the expression of PTEN gene and PTEN gene mutation in human glioma.Methods One hundred and two paraffin embedded glioma tissues were analysed for PTEN gene expression and PTEN gene mutation by immunohistochemical methods and PCR SSCP technique.Results The PTEN positive staining was found in plasma.The positive rate was 53 9%(55/102),and the positive rates decreased with progression of pathological grade, P 0 01;11 of PTEN gene mutations was identified in 42 glioblastomas,1 of PTEN gene mutation was identified in other gliomas,and the ratio of PTEN gene mutation in glioblastomas was significantly different from that of the other gliomas,χ 2=11 62, P 0 01.Conclusion PTEN gene mutation or deletion may have an important effect on the generation and development of glioma.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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