Title: Apoptosis of hepatocellular carcinoma HepG2 cells induced by ginsenoside modifier PM1
Abstract: Objective:To study the effect of PM1 on inducing apoptosis of HepG2 cells in vitro.Methods:The HepG2 cells were treated with different doses of PM1.Cell proliferation was measured by MTT assay.Cell cycle and apoptosis rate were analyzed by flow cytometry.Results:PM1 inhibited proliferation of HepG2 cells in concentration-dependent manner.FCM assay showed that PM1 regulated cell cycle and induced apoptosis of HepG2 cells after treated with 50 and 100 mg/L PM1 for 24 h.The apoptosis rates were increased(P0.01).Conclusion:PM1 probably inhibits the proliferation of HepG2cells by inducing apoptosis.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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