Title: Spectrophotometric method for determination of aciclovir with bromothymol blue and its analytical applications
Abstract: In a NaH2PO4-Na2HPO4 buffer medium with pH 7.20,the aciclovir reacts with bromothymol blue to form an ion-association complex,and the colours of the solution change obviously,with the maximum absorption wavelength occurring at 614 nm and the obvious fading color existing at 438 nm.The concentration of aciclovir in the range of 2.45×10-6~2.24×10-5 mol/L obeys the Beer′s law at the maximum absorption wavelength of 614 nm,and the apparent molar absorptivity is 1.98×104 L·mol-1·cm-1,while the detection limit is 8.16×10-7 mol/L.The method has a high sensitivity and a fairly good selectivity.This method can be applied to the determination of aciclovir in medicine samples and human serum and human urine with satisfactory results.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot