Title: Experimental research on Th1/Th2 cytokines in nonalcoholic steatohepatitis rats by Gongdu Fuzheng therapy
Abstract: Objective: To observe the experimental research on effect of Th1/Th2 in nonalcoholic steatohepatitis rats by Gongdu Fuzheng therapy.Methods: Experimental animal models of NASH were established,treated with Qingre Jiedu granules,Yangyin Huoxue granules,simvastatin solution.After 4 weeks,determine liver tissue TNF-α,IFN-γ,IL-4,IL-6 levels by ELISA.Results: TNF-α,IL-4,IL-6 levels increased,IFN-γ decreased in the model group compared with the normal liver tissue,and the difference was statistically significant(P0.01).Treatment group for TNF-α,IL-4,IL-6 had a negative regulatory role,so that content could be reduced,while treatment for the IFN-γ had a positive regulatory role,and could adjust Th1/Th2 the overall state of disorder.Conclusion: NASH rats had Th1/Th2 type cytokine network disorder,and Gongdu Fuzheng therapy could adjust disorder state.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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