Title: In vitro inhibitory effect of genistein on invasion and proliferation of human ovarian cancer cell line SKOV3
Abstract: 【Objective】 To examine the inhibitory effect of genistein on invasion and proliferation of human ovarian cancer cell line SKOV3.【Methods】 The SKOV3 cell line was exposed to various concentration of genistein.Methyl thiazolyl tetrazolium(MTT) assay and colon formation assay were used to observe the growth inhibition rate of SKOV3 cell line.Cell adhesion test and transwell assay were used to evaluate the adhesive,migration and invasion ability of SKOV3 cell line.【Results】 Genistein could inhibit the growth of SKOV3 cell line,and this inhibition was in a dose-dependent pattern(P 0.05).Genistein could reduce abilities of migration and invasion in SKOV3 cell line in a dose-dependent pattern significantly(P 0.05).【Conclusions】 Genistein can inhibit the proliferation and invasion ability of ovarian cancer in vitro.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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