Title: Effects of Sufentanil-propofol and Sufentanil-sevoflurane on Stress Response and Anesthetic Recovery in Elderly Patients Undergoing CO_2 Pneumoperitoneum
Abstract: Objective To investigate the effects of sufentanil-propofol and sufentanil-sevoflurane on stress response and anesthetic recovery in elderly patients undergoing laparoscopic cholecystectomy(LC).Methods Forty ASA Ⅰ or Ⅱ patients,male or female,aged 60-75 years,using the Supreme-LMA management airway for general anesthesia during LC,were randomly divided into two groups(n = 20):sufentanil-propofol group(group P) and sufentanil-sevoflurane group(group S).MAP and HR were recorded separately at different time points as follows:after entering the operating room(T0),the time before pneumoperitoneum(T1),20 min after pneumoperitoneum(T2) and 5 min after extubation(T3).Venous blood samples were taken at T0-T3 to determine the concentrations of adrenocorticotrophichormone(ACTH),cortisol(Cor),epinephrine(E) and norepinephrine(NE) in plasma.Also,the recovery time of spontaneous respiration,eye-open after called,the awake time of consciousness,extubation time and Steward score were recorded.Results The MAP and HR were maintained in the normal range during operation in both groups.Compared with at T0,there was no significant difference of Cor or NE concentration in plasma at T1,T3 in neither group P nor group S(P 0.05);MAP and HR were significantly decreased in group P but increased in group S;plasma ACTH,Cor,E and NE were significantly decreased in group P while significantly increased in group S at T2 as compared with the baseline before anesthesia at T0(P 0.05).The concentrations of ACTH and E in plasma at T3 were different between group P and group S(P 0.05).No statistic difference was observed in the recovery time of spontaneous respiration,eyes-open,the awake time of consciousness,extubation time and Steward score of both groups(P 0.05).Conclusion The anesthesia with sufentanil-propofol for the elderly patients during LC could better suppress the stress response than sufentanil-sevoflurane without obviously influence on anesthetic recovery.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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