Title: A clinicopathologic study of breast encapsulated papillary carcinoma
Abstract: Purpose To elucidate the clinicopathologic features of encapsulated papillary carcinoma(EPC) of the breast.Methods The clinicopathologic features and immunohistochemical results of 17 cases of breast EPC were reviewed.The antibody used for immunohistochemical staining included p63,SMA,CK5/6,ER,PR,HER-2 and Ki-67.Follow-up data for the patients was got.Results Of the 17 EPC patients,16 were females,with a mean age of 62 years.Palpable mass and nipple discharge were the most common symptoms.EPCs ranged in size from 1.5 to 5.5 cm(mean 2.9 cm),and 10 cases were cystic.Microscopic examination showed single or multiple lesions surrounded by a rim of fibrous connective tissue.The majority of EPCs demonstrated the classic features of a papillary architecture lined by tall columnar epithelial cells.The minority presented a cribriform or solid glandular pattern.One patient had metastasis carcinoma in 1 axillary lymph node.Myoepithelial cell staining was negative for p63,SMA and CK5/6 within the tumor and at the periphery of the tumor.The tumor cells were positive for ER and PR.Only 1 case showed 2(﹢) staining for HER-2,and the rest were negative.The average positive percentage for Ki-67 was 12%.Follow-up was available in 10 cases,and no patient had recurrence,distant metastasis or death.Conclusions EPC lacking a peripheral layer of myoepithelial cells can be regarded as a special type of invasive carcinoma associated with better prognosis,and can be treated like the therapy of DCIS.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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