Title: Oxidation damage of airborne fine particulate matter on brains of rats
Abstract: Objective To investigate the toxicological mechanism of airborne fine particulate (PM_ 2.5) on brains of rats.Methods 32 male wistar rats were randomly divided into PM_ 2.5 exposure groups at different concentration (1.5,7.5,37.5?mg/kg) and control group instilled with physiological saline.Rats were killed 24?h after instillation,and the levels of thiobarbituric acid reactive substance (TBARS),Glutathione (GSH) and activities of superoxide dismutase (SOD),Glutathione peroxidase (GSH-Px),Catalase (CAT) were measured.Results The activities of SOD and CAT decreased with PM_ 2.5 concentration in a dose-depenent manner (P0.05).PM_ 2.5 instillation at 37.5?mg/kg caused statistically significant decrease of GSH level.(P0.05).The changes of GSH-Px activities and TBARS levels at all concentration were not statistically significent in comparison with control group.SOD/TBARS decreased significantly at all concentrations,and TBARS/GSH-Px increased significently at 37.5?mg/kg concentration (P0.05). Conclusion PM_ 2.5 could cause oxidative damage to brains of rats.It was a neural toxin.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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