Title: Developments of topoisomerase I inhibitors in cancer chemotherapy
Abstract:Following the realization that human DNA topoisomerase Ⅰ(Topo Ⅰ) is a useful therapeutic target against tumor growth,Topo Ⅰ inhibitors represent a class of effective agents that have been extensively ...Following the realization that human DNA topoisomerase Ⅰ(Topo Ⅰ) is a useful therapeutic target against tumor growth,Topo Ⅰ inhibitors represent a class of effective agents that have been extensively exploited and used for carcinoma chemotherapy.Current Topo Ⅰ inhibitors being clinically used or developed are classified as campotothecins and non-camptothecins.This presentation introduces current status and trends of Topo Ⅰ inhibitors as anti-tumor agents with an emphasis on bioactive and pharmacological properties of these agents.Read More
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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Cited By Count: 1
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