Title: COMPARISON OF THE COMPREHENSIVE EFFECT OF DIFFERENT TREATMENTS FOR THE LUPUS NEPHRITIS
Abstract: [Objective]To observe the comprehensive effect of Tacrolimus and Cyclosporine combined hormone in the therapy of lupus nephritis.[Methods]80 patients with active lupus nephritis were diagnosed by renal biopsies who with quantitative urinary protein 150g/24h,randomly divided into tacrolimus group[0.07-0.08mg/kg·d)]which had 40 cases and cyclopsorin group(3-5mg/kg·d)of 40 cases,and combination hormone therapy for six months.Mainly observed SLE-DAI,urinary protein,serum albumin,serum C3,anti-dsDNA and the ANA had positive changes before and after the treatment,and the treatment efficiently and adverse events before and after the treatment.[Results]The therapeutic effect and adverse events in the two groups were significantly different,with statistical significance.[Conclusion]TL combined with hormone comprehensive treatment for lupus nephritis has the ideal efficacy and safety.Compared with CsA and it can reduce the albuminuria and control the disease activity,reduce adverse reactions obviously,has the best treatment effect,is worthy in clinical application.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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