Title: The effect of total hepatic vascular exclusion on liver ischemia-reperfusion injury in rabbits with cholestasis
Abstract: Objective To explore the effect of total hepatic vascular exclusion (THVE) on liver ischemia reperfusion injury in rabbits with cholestasis.Methods Thirty rabbits were divided into three groups:normal control (group A),cholestasis (group B) and THVE (group C). During liver ischemia reperfusion,hepatic tissue oxygon pressure (PtiO 2) was monitored. Serum total bilirubin (TBIL) and glutamic pyruvic transaminase (ALT) were also measured. The histopathologic changes of liver were observed under light microscope.Results In the groups B and C,hepatic PtiO 2 value was significantly decreased after THVE. 60 min after ischemia reperfusion,hepatic PtiO 2 value was not restored,significantly different from that before ischemia (P0.05). At 60 min of reperfusion,the PtiO 2 values in the group B were restored much more slowly than in the group C (P0.05). The ALT values before liver ischemia in the groups B and C were (265.0±13.8) U/L and (44.5±3.9) U/L,respectively. At different time points of 24 h during liver ischemia reperfusion,ALT values were further increased,more significant in the group B than in the group C. At 7th day,ALT values in the groups B and C returned to normal levels,and so did the pathologic changes of hepatic cell injury.Conclusion During cholestasis,live could safely tolerate THVE (20 min) induced hepatic ischemia reperfusion injury.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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