Title: Clinical observation of transcatheter hepatic arterial chemoembolization combined with low-dose heparin and octreotid on extrahepatic metastasis of primary hepatocellular carcinoma
Abstract: Objective To evaluate the effect of transcatheter hepatic arterial chemoembolization(TACE) combined with low-dose heparin and octreotid on extrahepatic metastasis of primary hepatocellular carcinoma.Methods Both the control group and treatment group were treated by TACE.In addition,treatment group was treated by low-dose heparin(1250-2500U intervenous infusion,once a day for 10-14 days pre-operation) and SMS 201-995 octreotide(0.1mg hypodermic injection 30min pre-operation and intervenous infusion 72h with the speed of 25μg/h).The two groups underwent TACE once a month,and efficacy,quality of life and side effects were evaluated after 2-4 times treatment.Results There was no statistical significant of variation of primary lesion between the two group(P0.05).The incidence of tumor metastasis 3,6,9,12 months after TACE in control group was 4.7%,12.7%,12.7% and 25.4% compared with 1.1%,3.5%,3.5% and 4.8% in treatment group with statistic significance(P0.05).The arise of AFP level 6,9,12 month after TACE in control group was 7.9%,19.0% and 31.7% compared with 6.0%,9.5% and 11.9% in treatment group with statistic significance(P0.05).Quality of life,side effect and blood coagulation did not show difference between the two groups.Conclusion The incidence of tumor metastasis can be depressed by the combination of low-dose heparin and octreotide after TACE of primary hepatocellular carcinoma,and won't increase the side effect and influence on primary lesion and blood coagulation.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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