Title: The phenotypic analysis of Human fetal thymocytes
Abstract: The phenotypes of human fetal thymocytes has been analysed with fflowcytometry.The findings suggest that the composition of thymocyte subsets shows no obvious changes from the 17th week of gestation to birth.In the pieriod of human fetus,features of thymocyte phenotypes are showed:1.Expression density of CD3/TCRαβ shows a continuous distribution from low to high.According to the density of D3/TCRαβ,tyhmocytes can be divided into three subsets,that is,L—CD3/TCRαβ(low—density),M—CD3/TCRαβ medium—density)and H—CD3/TCRαβ(high— density).The proportion of three subsets is different in different fetuses.2.Single positive thymocytes express CD1 antigens.H—CD3/TCRαβ thymocytes also express CD1 antigens.But,Part of those thymocytes express low—density of CD1 antigens,other part of the hymocytes express high—density of CD1 antigens.3.HLA class Ⅰ antigen density varies with thymocytes.Most thymocytes express low density of HLA class Ⅰ antitgens,minor thymocytes express high density of HLA class Ⅰ
antigens.HLA class Ⅰ antigen density correlates with maturity of thymocytes.4.Thymocytes can be divided into two subsets:Thy-L and Thy-H on the basis of thymocyte special density by means of density gradient centrifugation.Thy-L subset includes more mature and early thymocytes than Thy-H subset,while thy-H subset includes much more common thymocytes than Thy-L subset.
Publication Year: 1992
Publication Date: 1992-01-01
Language: en
Type: article
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