Title: Effect of different resuscitation pressure on uncontrolled hemorrhagic shock in rats
Abstract:Objective To compare the effect of different resuscitation pressure on resuscitation outcome of uncontrolled hemorrhagic shock.Methods Sixty four Wistar rats were divided into 8 groups(n=8/group) and ...Objective To compare the effect of different resuscitation pressure on resuscitation outcome of uncontrolled hemorrhagic shock.Methods Sixty four Wistar rats were divided into 8 groups(n=8/group) and anesthetized with sodium pentobarbital.Uncontrolled hemorrhagic shock was produced by spleen amputation and the mean arterial blood pressure(MAP) was drop to 40 or 50mm Hg.The management was divided into three phases.The first phase mimicked the prehospital emergency treatment,during which the shocked rats were resuscitated with lactated Ringer′s solution and 6% dextran to a MAP at 40,50,60,70,80 and 100mm Hg for 1h respectively,sham operated group and unresuscitated group were as control group.The second phase mimicked the definitive treatment of hospital,during this phase,the spleen artery was ligated and the rats was resuscitated to a MAP at 100mm Hg for 2h with fluid and blood.The third phase was 2h resuscitation effect observing period.The observed parameters included mean arterial blood pressure(MAP),hemodynamic parameters,hematocrit and animal survival time.Results The animals in the hypertensive(80,100mm Hg) resuscitation groups at early treatment had a short survival time,half of animals died at the first stage.They had a lower hematocrit and hemodynamics.In contrast,the animals in the hypotensive(50,60,70mm Hg) resuscitation groups had a longer survival time.Their hemodilution was not severe and their hemodynamics were superior to the hypertensive resuscitation groups.But too low resuscitation pressure(40mm Hg) was not good to shock resuscitation,the animal survival rate was not high,the survival time was lower than 50,60 and 70 mm Hg groups and close to 80mm Hg group.Conclusion Hypertensive resuscitation for uncontrolled hemorrhagic shock in prehospital phase will increase the blood loss and interfere with the resuscitation effect.Proper hypotensive resuscitation(50-60mm Hg) in early stage will benefit to the stabilization of hemodynamics and shock resuscitation.But too low resuscitation pressure was not good to shock resuscitation because of insufficient tissue perfusion.Read More
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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