Title: The mechanism of puerarin on strengthening insulin sensitivity in insulin resistant hypertensive rats
Abstract: OBJECTIVE To observe the effects of puerarin injection(Pue) on insulin sensitivity in insulin resistant hypertensive(IRH) rats.METHODS By feeding high fat-sugar-salt diet to set up the rat model of IRH.Five groups were designed: Captopril,Pue high dose,media dose,low dose,control group except normal group.The changes of blood pressure,blood glucose,serum triglyceride(TG),total cholesterol(TC),tumor necrosis factorα(TNF-α) and content of fasting plasma glucose and insulin were measured and insulin sensitivity index(ISI) was counted after 4 weeks treated. RESULTS All of the blood pressure,blood glucose and insulin were increased,had significant difference between the model group and normal group(P0.05~(0.01)).Compared with the model control,groups of captopril and Pue 80mg kg~(-1) could decrease the content of TNF-α,correct hyperinsulinemia(P0.05~(0.01)),promote the ISI lowered(P0.01)in IRH rats.And there were no significant difference between the other two doses groups of Pue in Fins,TNF-αand ISI(P0.05).Groups of catopril,Pue 80mg·kg~(-1)and group 40mg·kg~(-1) could decrease the contents of TG,TC(P0.05~0.01).And there was no difference in all above data in the group Pue 20mg·kg~(-1)(P0.05).CONCLUSION Puerarin can decrease the content of TNF-α,and control hyperinsulinemia and blood glucose and lipids metabolic disturbance,improve the insulin sensitivity in IRH rats.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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