Title: Application of prostaglandin E_1 to ventricular septal defect and pulmonary hypertension in infants
Abstract:Objective To study the selective action of prostaglandin E 1 (PGE 1) on reducing resistance of pulmonary artery and arterioles in ventricular septal defect with pulmonary hypertension in infants. Meth...Objective To study the selective action of prostaglandin E 1 (PGE 1) on reducing resistance of pulmonary artery and arterioles in ventricular septal defect with pulmonary hypertension in infants. Methods Eighteen infants (male 13, female 5) suffering from ventricular septal defect with pulmonary hypertension were evaluated. Their age ranged from 5 months to 6 years (mean, 29.67 ± 23.14 mon).The hemodynamics and cardiac output were measured via right cardiac catheterization. The Pp/Ps ratio in this group was more than 0.45 . All cases were administered PGE1 by intravenous pump with a dose of 50~ 100?ng/kg ·min for two weeks preoperatively. The same measurements were repeated during open heart operation before the bypass. Results Compared with the measurements before the use of PG E 1, there was an obvious decrease in pulmonary artery pressure, pulmonary capillary wedge pressure, total pulmonary vascular resistance and pulmonary capillary resistance. However, the cardiac output was markedly increased from 2.58 ± 0.58 to 3.87 ± 1.03 ?L/min ( P 0.001 ). No significant change was found in both the systemic pressure and Qp/Qs ratio ( P 0.05 ). The follow up results of all subjects for a period of two years were satisfactory. Conclusions PGE 1 has the selective action on pulmonary vasodilatation . It effectively reduces pulmonary arterial pressure and capillary wedge pressure, total pulmonary vascular and arterial resistance, and increases cardiac output simultaneously. The present study showed that the administration of PGE1 before operation could improve cardiac function and reduce postoperative pulmonary hypertension crisis without major adverse reaction in infants with VSD and pulmonary hypertension.Read More
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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