Title: Summary on Structure and Function of Polymeric Immunoglobulin Receptor(Pigr) in Teleost
Abstract: The polymeric immunoglobulin receptor(pIgR) was a type I transmembrane protein,mediating secretory polymeric immunoglobulins(Ig)transporting across epithelial cells,and had been cloned in a variety of higher vertebrates.The pIgR gene was cloned in Takifugu rubripes,Danio rerio,Cyprinus carpio one after another since 2007,and the expression was ananlyzed.The teleost pIgR contained two immunoglobulin-like domains and four conservative Cys residues,which could bind polymeric immunoglobulins better,and mediated polymeric immunoglobulins to skin mucus or intestine mucus.However,the function and mechanism of the pIgR gene was still known little.This paper intended to do a brief overview on molecular structure,transcytosis,function and the different expression pattern of pIgR in teleost,which would provide guidance for future study in-depth on the function and the transport mechanism of pIgR in mucosal immunity.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
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