Title: Analysis of correlation factors of intrauterine interruption failure for HBV infected pregnant women using HBIG during in the last trimester of pregnancy
Abstract: Objective:To study the failure rate of interruption interuterine HBV infection of the pregnant women whose HBV-DNA is positive and used HBIG to interrupt interuterine infection during the last trimester,and analyze the correlation factors of intrauterine interruption failure.Methods:250 pregnant women with HBsAg and HBV-DNA positive who were given HBIG 200IU every 2 weeks during the laster trimester.Divide them into 4 groups as group 1,2,3,4 whose blood titer of HBV is 106grade,106grade,107grade,≥108grade respectively to analyze the relaitionship between intrauterine interruption failure rate and serum virus content.114 women with high blood titer of HBV were divided into 2 groups according to whether their infants were intrauterine infected to analyze other factors.Results:20 of 248 newborns were intrauterine infected by HBV.The failure rate of the four groups is 0.74%,8.33%,15.38%,41.67%,respectively.The value of association between the HBV infection rate and virus content in gravida′serum showed statistical significance.HBeAg content showed statistical significance between the successful group and the interuterine HBV infection group.But age,gravidity and parity,gestational age,way of delivery,threatened abortion or premature dilivery,gender of infants didn't showe statistical significanc.The content of HBcAb in high titer of virus descented more quickly than the low titer of virus group and have statistical significance.Conclusions:The main factor of interuterine interruption failure is high HBV DNA content of pregnant women.It may be concerned with HbcAb content in the infants'serum.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot