Title: [Effects of hypothyroidism on Goalpha gene expression in hippocampus and dentate gyrus during early development of rat brain].
Abstract: To study the expression of Goalpha mRNA in hippocampus and dentate gyrus of 7-day rats with hypothyroidism.We use wistar rat model of hypothyroidism and non-radioactive in situ hybridization technique to observe the changs of Goalpha mRNA levels in hippocampus and dentate gyrus of 7-day rats with or without hypothyroidism.Perinatal hypothyroidism can increase Goalpha mRNA levels in all areas of hippocampus and dentate gyrus of 7-day rats.Thyroid hormone can down-regulate Goalpha gene transcription in hippocampus and dentate gyrus during the early development of rat brain.
Publication Year: 2001
Publication Date: 2001-02-01
Language: en
Type: article
Indexed In: ['pubmed']
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