Title: Study on silk fibroin/nano-bioactive glass porous composite scaffolds
Abstract: In this paper,the silk fibroin/nano-bioactive glass(SF/NBG) porous composite scaffolds were prepared by freezing-drying and characterized by X-ray diffraction(XRD),fourier transform infrared spectroscopy(FT-IR) and scanning electron microscopy(SEM).The results showed that SF/NBG composite scaffolds had better interconnected porous structures,and the pore size was about 150 to 300μm,the porosity was between 80.6% and 90.3%.Simultaneously,the conformation of silk fibroin was promoted to change from random coil to β-sheet structure with NBG added into it.Porous composite scaffolds had higher compressive strength and compressive modulus compared to pure SF porous scaffold.The bioactivity in vitro of composite scaffolds were studied through immersing it into simulated body fluid,the samples were also characterized by XRD,FT-IR and FESEM.The results indicated that hydroxyapatite(HA) layers were formed on the porous composite scaffolds after immersed in SBF for seven days,the speed of HA deposition was accelerated with NBG adding into SF.The result was that SF/NBG porous composite scaffolds were expected to be as good bioactivity materials for bone tissue repairing.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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