Title: Multi-center clinical trial of Yifuning capsule in the treatment of vaginal bleeding patients after medical abortion
Abstract: Objective:To evaluate the efficacy and safety of Yifuning capsule in the treatment of vaginal bleeding patients after medical abortion.Methods:Patients who had vaginal bleeding after medical abortion with blood stasis syndrome (n=420) were recruited in a randomized,double-blind,placebo-paralleled control,multi-center clinical trial.The patients were randomly divided into 2 groups,and received a 7-day (twice a day) treatment of Yifuning capsules or placebo from the moment of foetal sac outing.The efficacy was evaluated 7 days after treatment by the vaginal bleeding time,vaginal bleeding loss,syndrome,Hb,the first time menstrual after medical abortion and full-abortion rate.The safety was evaluated based on the incidences of adverse events and laboratory examination.Patients were followed up until the first time of menstrual onset after medical abortion.Results:In FAS,the mean vaginal bleeding time was 229.10 h (9.54 days) in Yifuning group,and 331.39 h (13.81 days) in placebo group.In PPS,the mean vaginal bleeding time was 222.18 h (9.26 days) in Yifuning group,and 327.32 h (13.64 days) in placebo group.The differences between two groups were significant in the vaginal bleeding time,the vaginal bleeding loss and curative effect on syndrome.Conclusion:Yifuning capsule provides an effective and safe therapeutic option for vaginal bleeding after medical abortion in patients with blood stasis syndrome.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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