Title: Comparison of anti-inflammatory effects between methotrexate and Yangqixue Qufengshi Recipe on mice arthritis induced by collagen II
Abstract:Objective To compare the anti-inflammatory effects between methotrexate(MTX) and Yangqixue Qufengshi Recipe(YQXQFSR) on mice arthritis induced by collagen II.Methods The model of rheumatoid arthritis ...Objective To compare the anti-inflammatory effects between methotrexate(MTX) and Yangqixue Qufengshi Recipe(YQXQFSR) on mice arthritis induced by collagen II.Methods The model of rheumatoid arthritis was induced by using collagen II in C_(57)BL/6×DBA/1 mice.The rats with arthritis were treated with MTX or YQXQFSR respectively.The indexes such as the onset day of collagen induced arthritis(CIA),the level of CII-reactive antibodies and the pathological scores of CIA were assessed.Results The onset day of CIA and the level of CII-reactive antibodies were not influenced in the treatment of mice arthritis with MTX and YQXQFSR respectively.But MTX could alleviate the damage of cartilage [(1.60±1.51) vs(3.56±1.33) scores,P0.05]and bone erosion [(0.30±0.69) vs(1.67±1.50) scores,P0.01].YQXQFSR could only alleviate bone erosion [(0.22±0.44) vs(1.67±1.50) scores,P0.01].Conclusion MTX can alleviate the damage of cartilage and bone erosion,and YQXQFSR can alleviate bone erosion.The mechanisms of MTX and YQXQFSR on the treatment of rheumatoid arthritis are different.Read More
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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