Title: Study on the clinical significance of N-terminal pro-brain natriuretic peptide in assessment of severity and prognosis of heart failure
Abstract: Objective To study the change in N-terminal pro brain natriuretic peptide(NT-ProBNP) in different types of heart failure,and to evaluate the relationship between changes of NT-ProBNP and the severity,prognosis of patients with heart failure.Methods A total of 89 patients with heart failure were divided into diastolic heart failure group(DHF group,n = 26 cases),systolic heart failure group(SHF group,n = 63 cases),and 52 healthy persons as control group.The concentration of plasma NT-ProBNP and changes in ultrasound Beckoning figure index were studied.The relationship between concentration of NT-ProBNP in patients with heart failure and NYHA classification for heart function also has been studied.The changes in NT-ProBNP of patients with heart failure before and after treatment were studied.The significance of NT-ProBNP as evaluation of the prognosis of patients with heart failure has been evaluated.Results The concentration of NT-ProBNP in control group,DHF group and SHF group increased successively.There was statistically significant difference between these groups(P 0.05).There was no correlation in NT-ProBNP Log Koc and left ventricular end diastolic dimension(LVEDD)(r = 0.426,P 0.05),left ventricular ejection fraction(LVEF)(r =-0.554,P 0.05) in DHF group.No correlation was found in SHF group.NT-ProBNP on numerical end diastolic diameter on the numerical and left ventricular(r = 0.569,P 0.05) were positively correlated.NT-ProBNP on the numerical value and left ventricular ejection fraction(r =-0.621,P 0.05) was negatively correlated.Different NYHA classification of cardiac function of heart failure in each group of NT-ProBNP on numerical significantly(P 0.05).NT-ProBNP on the cardiac function of numerical and NYHA classification were positively correlated(r = 0.663,P = 0.000,P 0.05).Heart failure before and after treatment,IV level of NT-ProBNP on the numerical decline,LVEF rise,left ventricular end diastolic diameter decreased,inter group were statistically significant(P 0.05).Conclusion NT-ProBNP has higher sensitivity in the early diagnosis of heart failure,the close relationship between the increased with the severity,clinical significance for prognosis,prognostic evaluation are important.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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