Title: Expression profile of cancer-testis genes in urinary transitional cell carcinomas
Abstract: Objective:To evaluate the significance of 4 individual cancer-tesits(CT) gene expression in bladder transitional cell carcinomas.Methods: cTAGE-1,cTAGE-2,MAGE-A1,NY-ESO-1 expression were detected by reverse transcription polymerase chain reaction(RT-PCR) in 49 samples of bladder transitional cell carcinoma patients(Ta-T1 28 samples,T2-T4 21 samples,G1 20 samples,G2 16 samples,G3 13 samples) and 15 samples of adjacent tissues.Results The CT gene was detected with various frequencies in bladder transitional cell carcinoma tissue: MAGE-A1,59%(29/49);cTAGE-1,55%(27/49);cTAGE-2,51%(25/49) and NY-ESO-1,47%(23/49).In contrast,no CT gene expression was found in cancer adjacent tissues.We did not find any significant correlation between CT gene expression and disease stage or grade(P0.05).Conclusion: CT gene highly expressed in bladder transitional cell carcinoma and no CT gene expression was found in cancer adjacent tissues.It's probability to be target gene in bladder transitional cell carcinoma immunotherapy should be further explored.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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